Biomedical applications of magnetic nanoparticles for applications in new oncological therapies based on magnetic hyperthermia.
Subline 3.1.-Optimization of core-shell type magnetic nanoparticles for their application in biomedicine.
Core-shell nanoparticles of Fe @ C (physical methods) and Fe3O4 @ C (chemical methods) will be investigated for their evaluation and application as nano-carriers for local drug delivery.
Subline 3.2.–Development of new nanovectors based on magnetic nanoparticles encapsulated in inorganic, organic or liposomal-based coatings for stimulated drug delivery.
The controlled release mechanism pursued is based on the absorption of energy from an alternating electromagnetic field (AFM) of radio frequencies by magnetic nanoparticles incorporated into the thermosensitive vector that carries the drug. The NPMs transfer heat to the thermosensitive vector, initiating drug release. Different types of encapsulations will be investigated and simulation techniques will be developed to predict both the process of energy absorption and drug release.
Subline3.3.- Oncological immunotherapy based on magnetic nanoparticles mediated by dendritic cells and / or magnetic hyperthermia.
The effects of immunotherapy induced by incorporating functionalized magnetic nanoparticles with stimulating factors of the immune system in dendritic cells as well as those induced by magnetic hyperthermia using magnetoliposome-type nanovectors will be investigated.